发明名称 |
PEPTIDE CONJUGATES FOR THE STABILIZATION OF MEMBRANE PROTEINS AND INTERACTIONS WITH BIOLOGICAL MEMBRANES |
摘要 |
The present invention provides a novel class of detergents referred to herein as lipopeptide detergents. Lipopeptide detergents comprise an amphipathic alpha -helical peptide having a hydrophobic or neutral face and a hydrophilic face. To each end of this peptide is covalently linked an aliphatic hydrocarbon tail, these aliphatic tails being linked thereto such that they associate with the hydrophobic or neutral face of the peptide. Lipopeptide detergents can advantageously be used to stabilize membrane proteins in the absence of a phospholipid bilayer in a manner that preserves the native conformation and permits the subsequent crystallization thereof.
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申请公布号 |
WO0102425(A2) |
申请公布日期 |
2001.01.11 |
申请号 |
WO2000CA00773 |
申请日期 |
2000.06.29 |
申请人 |
UNIVERSITY HEALTH NETWORK;PRIVE, GIL |
发明人 |
PRIVE, GIL |
分类号 |
C07K14/00;C07K14/705;(IPC1-7):C07K1/00 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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