| 摘要 |
The human N-formyl receptor gene (I), including its 5' and 3' untranslated regions. Independent claims are also included for: (a) transcription factors, RNA polymerases, pharmaceuticals and chemicals that up- or down-regulate expression of (I); (b) mRNA (II), and its splice variants or isoforms, transcribed from (I); (c) cDNA derived from (II) or from genes without introns ; (d) protein (III) derived, or produced, from (II), cDNA or (I); (e) antibodies or antisera directed against one or more epitopes of (III) or the entire protein; (f) systems ( including eukaryotic cells, yeast cells, Xenopus Oocytes, Baculovirus systems, and bacterial expression systems) that express native or recombinant (III); (g) ligand binding studies and screening assays that use the native or recombinant receptor, or cells or membranes that contain it; (h) transgenic and knockout animals that express the receptor at altered level or not at all; (i) gene therapy method that involves the receptor or its gene, cDNA or mRNA; (j) (anti)sense oligonucleotides derived from (I); (k) diagnosis and treatment of diseases in which the receptor is (in)directly implicated; (l) development of new (or evaluation of known) pharmaceuticals, compounds, chemicals, and techniques; and (m) modified versions of the protein, gene, cDNA, and mRNA sequences.
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