A novel polypeptide; a DNA encoding the same; drugs containing the polypepti de or DNA; a method of screening a compound promoting or inhibiting the activit y of the above polypeptide or its salt; a screening kit therefor; the compound or its salt obtained by this screening; drugs containing the above compound or its salt and the like. The above-described polypeptide and the DNA encoding the same are usable, for example, in diagnosing, treating and preventing bon e and joint diseases and pathologic anagiogenesis. The polypeptide is also useful as a reagent for screening a compound promoting or inhibiting the activity of the polypeptide or its salt.
