摘要 |
<p>The objective bicyclic amino alcohol (IV) is produced by reacting nopinone (I) (starting material) with XCH2COOR1 (wherein X is halogeno; and R1 is alkyl) in the presence of an additive and a base to form a compound (II), converting the compound (II) into an oxime (III), and reducing the oxime (III) with aluminum hydride.</p> |