PROCESS FOR THE SYNTHESIS OF (R)-1-(3,5-BIS(TRIFLUOROMETHYL)-PHENYL)ETHAN-1-OL BY ASYMMETRIC TRANSFER HYDROGENATION

摘要

The present invention is concerned with a process for the preparation of (R) -1- (3,5-bis(trifluoromethyl)phenyl)ethanol by asymmetric transfer hydrogenation of 3,5-bis(trifluoromethyl)acetophenone using a rhodium of ruthenium catalys t and a ligand in the presence of an alcohol. Also claimed are specific complexes of (S,R)-1-amino-2-hydroxyindane with rhodium and ruthenium as wel l as a process for purifying (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethanol by means of its complex with 1,4-diazabicyclo[2.2.2]octane and the 2:1 complex of (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethanol with 1,4- diazabicyclo[2.2.2]octane.