| 发明名称 |
TAXANE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF |
| 摘要 |
The present invention is directed to a process for the preparation of (4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-isobutyl- 1-oxazolidine-5-carboxylic acid. This compound is useful as an intermediate for the synthesis of baccatine III and V derivatives substituted at the 13-position by a N-Boc-~- isobutyl-serinyl residue. Such compounds show anticancer activity.
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| 申请公布号 |
CA2676424(A1) |
申请公布日期 |
2001.01.11 |
| 申请号 |
CA20002676424 |
申请日期 |
2000.07.03 |
| 申请人 |
INDENA S.P.A. |
发明人 |
GABETTA, BRUNO;PONTIROLI, ALESSANDRO;BOMBARDELLI, EZIO |
| 分类号 |
C07D263/06;C07D493/08;A61K31/335;A61K31/337;A61K31/36;A61P35/00;C07B61/00;C07D305/14;C07D493/04;C07D493/10 |
主分类号 |
C07D263/06 |
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