发明名称 TELOMERASE INHIBITORS AND METHODS OF THEIR USE
摘要 Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity <i>in vitro</i> and treatmnet of telomerase mediated conditions or diseases <i>ex vivo</i> and <i>in vivo</i> are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.
申请公布号 WO0102377(A1) 申请公布日期 2001.01.11
申请号 WO2000US18211 申请日期 2000.06.30
申请人 GERON CORPORATION;KYOWA HAKKO KOGYO CO., LTD.;CHIN, ALLISON, C.;HOLCOMB, RYAN;PIATYSZEK, MIECZYSLAW, A.;SINGH, UPINDER;TOLMAN, RICHARD, L.;AKAMA, TSUTOMU;KANDA, YUTAKA;ASAI, AKIRA;YAMASHITA, YOSHINORI;ENDO, KAORI;YAMAGUCHI, HIROYUKI 发明人 CHIN, ALLISON, C.;HOLCOMB, RYAN;PIATYSZEK, MIECZYSLAW, A.;SINGH, UPINDER;TOLMAN, RICHARD, L.;AKAMA, TSUTOMU;KANDA, YUTAKA;ASAI, AKIRA;YAMASHITA, YOSHINORI;ENDO, KAORI;YAMAGUCHI, HIROYUKI
分类号 C07D277/20;A61K31/426;A61K31/427;A61K31/4365;A61K31/4439;A61K31/454;A61K31/4709;A61K31/497;A61K31/506;A61K31/5377;A61P35/00;A61P43/00;C07D277/34;C07D277/36;C07D417/06;C07D417/10;C07D417/12;C07D495/04;C07D513/04;(IPC1-7):C07D277/34;A61K31/425;A61K31/44 主分类号 C07D277/20
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