摘要 |
Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity <i>in vitro</i> and treatmnet of telomerase mediated conditions or diseases <i>ex vivo</i> and <i>in vivo</i> are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.
|
申请人 |
GERON CORPORATION;KYOWA HAKKO KOGYO CO., LTD.;CHIN, ALLISON, C.;HOLCOMB, RYAN;PIATYSZEK, MIECZYSLAW, A.;SINGH, UPINDER;TOLMAN, RICHARD, L.;AKAMA, TSUTOMU;KANDA, YUTAKA;ASAI, AKIRA;YAMASHITA, YOSHINORI;ENDO, KAORI;YAMAGUCHI, HIROYUKI |
发明人 |
CHIN, ALLISON, C.;HOLCOMB, RYAN;PIATYSZEK, MIECZYSLAW, A.;SINGH, UPINDER;TOLMAN, RICHARD, L.;AKAMA, TSUTOMU;KANDA, YUTAKA;ASAI, AKIRA;YAMASHITA, YOSHINORI;ENDO, KAORI;YAMAGUCHI, HIROYUKI |