| 发明名称 |
OLIGONUCLEOTIDES INCORPORATING BOTH 2-AMINOADENINE AND 5-SUBSTITUTED PYRIMIDINES |
| 摘要 |
This invention presents oligonucleotides incorporating both 2-aminoadenine and 5-substituted pyrimidines together with a modified internucleoside linkage. In certain preferred embodiments, the 5-substituted pyrimidine is 5-methylcytosine. The oligonucleotides produced provide stronger hybridization to their target sequences. These oligonucleotides can be useful compounds, <i>inter alia</i> for diagnostic and therapeutic applications.
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| 申请公布号 |
WO0102608(A1) |
申请公布日期 |
2001.01.11 |
| 申请号 |
WO2000US18415 |
申请日期 |
2000.07.05 |
| 申请人 |
ISIS PHARMACEUTICALS, INC.;MANOHARAN, MUTHIAH;COOK, PHILLIP, DAN |
发明人 |
MANOHARAN, MUTHIAH;COOK, PHILLIP, DAN |
| 分类号 |
C07H21/00;C12N15/113;(IPC1-7):C12Q1/68;C12P19/34;C07H21/02;C07H21/04;A01N43/04 |
主分类号 |
C07H21/00 |
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