TRANSGENIC ANIMALS AS MODELS FOR NEURODEGENERATIVE DISEASE

摘要

There is provided transgenic animals comprising: 1.a nucleic acid vector (a) sequence encoding a human Tau protein; (b) a sequence capable of directing expression of said human Tau protein in the nervous system of a non-human animal; and (c) a targeting sequence which facilitates integration of said vector into the genome of said animal so as to prevent expression of equivalent Tau protein; a nucleic acid vector comprising: (a) a nucleic acid sequence encoding a human protein capable of modulating human Tau protein; (b) a sequence capable of directing expression of said protein in the nervous system of said animal; and (c) a targeting sequence capable of facilitating integration of said vector into the genome of said animal optionally at a position corresponding to a sequence in said animal encoding an equivalent of said human protein.