DIAGNOSIS OF CANCER BY DETECTING ASH2 POLYPEPTIDES OR POLYNUCLEOTIDES

摘要

The present invention provides methods for assessing the presence of a cancer in an animal. The methods provided herein are based on the surprising discovery that the ASH2 gene is amplified and/or overexpressed in multiple types of cancer cells. Accordingly, it has been discovered that the detection of overexpression or amplification of ASH2 in a biological sample from an animal allows the diagnosis of cancer in the sample. In addition, the present invention provides numerous methods for treating cancer, including by determining the most effective course of anti-cancer therapy based on ASH2 levels as well as by inhibiting the proliferation of cancer cells by inhibiting or reducing ASH2 polypeptide or polynucleotide levels.