| 摘要 |
organic chemistry, pharmacy. SUBSTANCE: invention relates to novel heterocyclic condensed benzoylguanidines of the general formula (I) where R1 and R2 mean independently each of other H or A; X means CR4R5, C=Z or O; Y means CR6R7; Z means O or CH2; R4,R5,R6 and R7 mean independently each of other H, A, OH or OA; or R5 and R6 or R7 and R8 mean in common a bond being in each molecule only a single similar bond can appear maximally; or R4 and R5 mean in common O-(CH2)2-O or O-(CH2)3-O, or R8 and R9 mean independently each of other H or A where A means alkyl with 1-6 C-atoms; n = 0 or 1, and their physiologically acceptable salts. Benzoylguanidines of the formula (I) are inhibitors of Na+/H+-anticarrier and used for preparing drugs. Invention describes also method of synthesis of compounds of the formula (I), pharmaceutical composition based on thereof and method of its preparing. EFFECT: new compounds indicated above, improved methods of synthesis and composition preparing, valuable pharmacological properties. 5 cl, 1 tbl
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