| 摘要 |
organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of azole of the general formula (I) where R1 and R2 are similar or different and each means hydrogen atom, cycloalkyl and so on; or R1 and R2 form with (a) the condensed ring (b) or (c) that can be optionally substituted with lower alkyl, amino-group and so on; R3,R6,R7,R8 are similar or different and each means hydrogen atom and so on; R4 means cyano-group, tetrazolyl, -COOR9 and so on; R5 means hydrogen atom or lower alkyl; D means optionally substituted lower alkylene; X and Z are similar or different and each means oxygen or sulfur atom; Y means -N= or =CH=; A means -B-O-, -S-B-, -B-S- or -B- where B means lower alkylene or lower alkenylene; n = 2. Derivatives of azole of the general formula (I) or their pharmaceutically acceptable salts with pharmaceutically acceptable carrier form pharmcomposition showing activity of antagonist of leukotriene and antagonist of thromboxane A2 that is useful for prophylaxis or treatment of allergic diseases, heart and brain ischemia. Intermediate compounds of the formula (IVc) and (IIIa) are given in the invention description. EFFECT: new compounds indicated above, valuable medicinal properties. 10 cl, 39 tbl, 156 ex
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