| 发明名称 |
Anti-alpha<sub>v</sub>beta3? recombinant human antibodies, nucleic acids encoding same and methods of use |
| 摘要 |
The invention provides enhanced LM609 grafted antibodies exhibiting selective binding affinity to αv&bgr;3, or a functional fragment thereof. The invention also provides nucleic acid molecules encoding the enhanced LM609 grafted antibodies. Additionally provided are methods of inhibiting a function of αv&bgr;3 by contacting αv&bgr;3 with an enhanced LM609 grafted antibody. |
| 申请公布号 |
AU5637400(A) |
申请公布日期 |
2001.01.09 |
| 申请号 |
AU20000056374 |
申请日期 |
2000.06.23 |
| 申请人 |
APPLIED MOLECULAR EVOLUTION |
发明人 |
WILLIAM D. HUSE;HERREN WU |
| 分类号 |
C12N15/09;A61K39/395;A61P9/10;A61P17/02;A61P17/06;A61P19/02;A61P19/10;A61P21/00;A61P27/02;A61P29/00;A61P35/00;A61P35/04;A61P43/00;C07K16/28;C12N15/12;C12N15/13 |
主分类号 |
C12N15/09 |
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