| 摘要 |
The product of a gene located at human chromosome 21q11-21 has ubiquitin specific protease activity and binds to ubiquitin, polyubiquitin, ubiquitin-like protein SUMO-3, and proteins which are implicated in the repair/excision of DNA. It is believed to have a role in regulating cell growth, cell growth arrest and/or apoptosis and is implicated in carcinoma growth. The gene has been sequenced and cloned into a microorganism and the product's effect on cell growth is to be investigated. The gene has GenBank accession number AF134213 and has the HUGO-approved name USP25. |
