发明名称 PERCUTANEOUS ESTROGEN AGONIST-ANTAGONIST THERAPY
摘要 PROBLEM TO BE SOLVED: To treat human requiring estrogen agonist-antagonist therapy by administering an effective amount of estrogen agonist-antagonist by percutaneous means. SOLUTION: An effective amount of estrogen agonist-antagonist [preferably a compound of formula I (G is a group of formula II or the like; R is H, OH, F or Cl), e.g. (-)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)-phenyl]-5,6,7,8- tetrahydronaphtharene-2-ol is administered by percutaneous means (preferably percutaneous patch). Preferably, the estrogen agonist-antagonist is administered to human in a substantially equivalent amount of 10-500μg/day for 3 to 14 days.
申请公布号 JP2001002588(A) 申请公布日期 2001.01.09
申请号 JP20000158026 申请日期 2000.05.29
申请人 PFIZER PROD INC 发明人 DA SILVA-JARDINE PAUL ANDREW
分类号 A61K31/435;A61K9/70;A61K31/40;A61K31/439;A61K31/445;A61K31/4453;A61K45/00;A61P3/04;A61P3/06;A61P5/30;A61P5/32;A61P9/00;A61P15/00;A61P19/10;A61P35/00;(IPC1-7):A61K45/00 主分类号 A61K31/435
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