发明名称 |
NOVEL QUATERNARY AMMONIUM DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL USE |
摘要 |
The invention concerns compounds of formulae (Ia) or (Ib) wherein M: represents a molecule for use in the treatment or diagnosis of pathologies affecting the cartilage; R1, R2, R3 represent an alkyl group, or R1, R 2, R3 together with the nitrogen atom which bears them form a heterocycle; X represents a C1-C6 alkyl chain wherein one or several -CH2- groups are optionally substituted by a sulphur, an oxygen atom, a -NR, -CO-, -CO-NH-, -CO2-, SO- or SO2- group; n represents 0 or 1; Hal represents a halogen atom, or the formula (Ib); R4 represents an alkyl group; Hal represents a halogen atom. General formula (F1) represents a molecule for use in the treatment or diagnosis of pathologies affecting the cartilage, provided that the nitrogen atom can optionally be included in a saturated or unsaturated nitrogenous heterocyclic system, or involved in a double bond.
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申请公布号 |
WO0100621(A1) |
申请公布日期 |
2001.01.04 |
申请号 |
WO2000FR01731 |
申请日期 |
2000.06.22 |
申请人 |
ADIR ET COMPAGNIE;MADELMONT, JEAN-CLAUDE;GIRAUD, ISABELLE;NICOLAS, COLETTE;MAURIZIS, JEAN-CLAUDE;RAPP, MARYSE;OLLIER, MONIQUE;RENARD, PIERRE;CAIGNARD, DANIEL-HENRI |
发明人 |
MADELMONT, JEAN-CLAUDE;GIRAUD, ISABELLE;NICOLAS, COLETTE;MAURIZIS, JEAN-CLAUDE;RAPP, MARYSE;OLLIER, MONIQUE;RENARD, PIERRE;CAIGNARD, DANIEL-HENRI |
分类号 |
A61K31/165;A61K31/4045;A61K31/5415;A61K31/555;A61K31/7008;A61K49/00;A61K51/00;A61P19/00;C07C231/12;C07C237/20;C07D259/00;C07D279/02;C07D409/06;C07D417/12;C07F13/00;C07H5/06;C07H15/12;(IPC1-7):C07D409/06;C07H15/26 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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地址 |
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