MEMBRANE-ASSOCIATED AND SECRETED PROTEINS AND USES THEREOF

摘要

The invention provides isolated nucleic acid molecules, designated INTERCEPT 340, MANGO 003, MANGO 347, TANGO 272, TANGO 295, TANGO 354, and TANGO 378 which encode wholly secreted or membrane-associated proteins. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.