| 摘要 |
<p>This invention concerns the compounds of formula (I), prodrugs, N-oxides, addition salts, quaternary amines, metal complexes or stereochemically isomeric forms thereof wherein -a?1=a2-a3=a4¿- is a radical of formula -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N- wherein each hydrogen atom may optionally be substituted; Q is a radical of formula (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7), (b-8), wherein Alk is C¿1-6?alkanediyl; Y?1¿ is a bivalent radical of formula-NR2- or -CH(NR?2R4)-; X1 is NR4¿, S, S(=O), S(=O)¿2?, O, CH2, C(=O), CH(=CH2), CH(OH), CH(CH3), CH(OCH3), CH(SCH3), CH(NR?5aR5b), CH¿2-NR?4 or NR4-CH¿2; X2 is a direct bond, CH¿2?, C(=O), NR?4, C¿1-4alkyl-NR?4, NR4-C¿1-4alkyl; t is 2 to 5; u is 1 to 5; v is 2 or 3; and whereby each hydrogen in Alk and in (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8), may optionally be replaced by R3; provided that when R3 is hydroxy or C¿1-6?alkyloxy, then R?3¿ can not replace a hydrogen atom in the α position relative to a nitrogen atom; G is substituted C¿1-10?alkanediyl wherein the substituent is attached via an oxygen atom; R?1¿ is an optionally substituted monocyclic heterocycle or aryl; R2 is hydrogen, formyl, C¿1-6?alkylcarbonyl, Hetcarbonyl, pyrrolidinyl, piperidinyl, homopiperidinyl, C3-7cycloalkyl or C1-10alkyl substituted with N(R?6)¿2 and optionally with another substituent; R3 is hydrogen, hydroxy, C¿1-6?alkyl, C1-6alkyloxy, arylC1-6alkyl or arylC1-6alkyloxy; R?4¿ is hydrogen, C¿1-6?alkyl or arylC1-6alkyl; R?5a, R5b, R5c and R5d¿ are hydrogen or C¿1-6?alkyl; or R?5a and R5b, or R5c and R5d¿ taken together form a bivalent radical of formula -(CH¿2?)s- wherein s is 4 or 5; R?6¿ is hydrogen, C¿1-4?alkyl, formyl, hydroxyC1-6alkyl, C1-6alkylcarbonyl or C1-6alkyloxycarbonyl; aryl is optionally substituted phenyl; Het is pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl; as respiratory syncytial virus replication inhibitors; their preparation, compositions containing them and their use as a medicine.</p> |
