| 摘要 |
<p>Compounds of the structural formula (1) or pharmacologically acceptable salts thereof, useful as intermediates for the preparation of nonnatural oligonucleotide analogues or 2-5A analogues which exhibit an excellent antisense or antigene activity and are stable <i>in vivo</i>: wherein R<1> and R<3> are each independently hydrogen, a hydroxyl-protecting group for nucleic acid synthesis, or the like; R<2> is hydrogen, C1-C6 alkyl, or an amino-protecting group for nucleic acid synthesis; and B is a purin-9-yl or 2-oxo-1,2-dihydropyrimidin-1-yl group which may have a substituent selected from among halogeno, C1-C6 alkyl, hydroxyl, mercapto, amino and so on.</p> |
