HEXAHYDROPYRROLO[1,2-C]PYRIMIDINES AS ANTIVIRAL, ANTIFUNGAL AND/OR ANTITUMOR AGENTS

摘要

Improved methods for convergent, total enantioselective synthesis of guanidinium alkaloid compounds including ones having cis- or - trans-1-oxo- and 1-iminohexahydropyrrolo[1,2-c]pyrimidine units including, 13,14,15-isocrambescidin 800, crambescidin 800 and ptilomycalin A , for use as therapeutic agents having antifungal and/or antiviral and/or antitumor activity are provided. Methods for preparing novel pentacyclic intermediates for the preparation of the crambescidin/ptilomycalin family of guanidinium alkaloids and congeners are also disclosed.