GOODPASTURE'S SYNDROME MODEL MOUSE

摘要

A non-human model animal of Goodpasture's syndrome contributing to the treatment of Goodpasture's syndrome the development of therapy for which has been delayed due to the lack of adequate disease models; a method for screening a remedy for Goodpasture's syndrome by using the model animal; and a method for diagnosing Goodpasture's syndrome at the early stage. An immunoglobulin Fc.gamma. receptor IIB knockout mouse is immunized with type IV collagen to induce Goodpasture's syndrome, thereby constructing a model mous e of Goodpasture's syndrome. Then test substances are administered to the mode l mouse and thus a remedy for Goodpasture's syndrome is screened based on the evaluation of the severity of the expression of Goodpasture's syndrome (i.e. , diffuse alveolar hemorrhage, glomerulonephritis, the appearance of antikidne y glomerular basement membrane antibody, etc.).