摘要 |
The present invention is directed to a peptide of formula (I), as defined herein, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising said peptide of formula (I), and the use thereof to restore apoptosis in human tumor cells. A compound of formula (I) of the present invention is R-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-NH R1 or a pharmaceutically acceptable salt thereof wherein, R is (C1-C5)acyl; A1 is absent or an aliphatic amino acid; A2 is absent or is selected from the grou p consisting of Gly, Ala, Ser, Thr and Asn; A3 and A4 are each absent or are each a coded amino acid; A5 is an aliphatic amino acid; A6 is Ala or a basic amino acid; A7 is selected from the group consisting of Ile, Leu, Val, Ser, Thr, Lys and Arg; A8 is an aliphatic amino acid; A9 is Gly; A10 and A11 are each independently Asp or Glu; A12 is an aliphatic amino acid Ile, Leu, Met and Val; A13 is Asp, Glu or Asn; A14 and A15 are each independently absent o r selected from the group consisting of Ile, Leu, Val, Met, Ser, Thr, Asn, Lys and Arg; and R1 is (C1-C5)alkyl.
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