发明名称 |
SELF-INDUCED DELETION OF DNA |
摘要 |
The present invention is directed to a method for deleting DNA sequences in a tissue specific manner. In one embodiment, DNA sequences are specifically deleted in germline tissue. In a second embodiment, DNA sequences are specifically deleted in desired somatic tissue. The present invention is further directed to a nucleic acid molecule for use in the method. More specifically, a nucleic acid molecule is provided by the present invention which comprises (a) a recombinase site, (b) a tissue-specific promoter, (c) a recombinase gene, (d) a foreign DNA, and (e) a recombinase site. The nucleic acid molecule may further comprise a gene which is desired to be incorporated into and expressed in a transgenic organism. The method can be used in both plants and animals, and has many applications as described herein.
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申请公布号 |
WO0100809(A1) |
申请公布日期 |
2001.01.04 |
申请号 |
WO2000US17828 |
申请日期 |
2000.06.29 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
THOMAS, KIRK, R.;BERNSTEIN, KENNETH, E.;BUNTING, MICHAELINE;GREER, JOY;CAPECCHI, MARIO |
分类号 |
A61K48/00;C12N15/63;C12N15/67;(IPC1-7):C12N15/00;C12N15/09;C12N5/00;A01N43/04;A61K31/70 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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