发明名称 |
INDOLE AND INDAZOLE UREA-PEPTOIDS AS THROMBIN RECEPTOR ANTAGONISTS |
摘要 |
The invention is directed to novel indole and indazole urea-peptoid compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indole and indazole urea-peptoid compounds of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
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申请公布号 |
WO0100576(A1) |
申请公布日期 |
2001.01.04 |
申请号 |
WO2000US18021 |
申请日期 |
2000.06.29 |
申请人 |
ORTHO-MCNEIL PHARMACEUTICAL, INC.;COR THERAPEUTICS, INC. |
发明人 |
MCCOMSEY, DAVID, F.;HOEKSTRA, WILLIAM, J.;MARYANOFF, BRUCE, E.;ZHANG, HAN-CHENG |
分类号 |
A61P7/02;C07D209/14;C07D231/56;(IPC1-7):C07D209/14;A61K31/404;A61K31/416 |
主分类号 |
A61P7/02 |
代理机构 |
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