| 摘要 |
The invention relates to new polycation bioconjugates and to a method for producing them. New polycation bioconjugates according to the invention are characterized by that the comprised polycations are capable of transporting active substances of different types in the mammal organism, i.e. for functioning as carrier molecules, thus are able to enhance the biological effectiveness of the transported molecules, and consequently they can, for example, favourably inhibit malignant cell proliferation, or they possess antimicrobial effect, or are suitable for transportation of genes. A further characteristic of the polycation bioconjugates according to the invention is that each of them contains isopolypeptide carrier molecules, bearing free alpha -amino group, as a common characteristic structural element. Enhancer molecules - same or different - having appropriate binding functions are coupled by chemical bonds directly and/or indirectly through connecting molecules - that may be identical or different ones - to the carrier molecule. Hence the polycation bioconjugates synthetized according to the invention are of general formula (I) wherein: "r" is a mean value between 20 and 400, "m"=0, 1, 2, 3, ...k, "[(k)Mx]" designates enhancer molecules and/or connecting molecules conjugated by covalent (=k) bonds to the isopolypeptide polycation carrier molecule, and "[(i)Mx]" designates enhancer molecules conjugated by ionic (=i) bonds to the isopolypeptide polycation carrier molecule, whereas the said enhancer molecules and connecting molecules having appropriate functional groups for conjugation may either be identical ones or of (two or more i.e "x") different kinds, and the enhancer molecules can be conjugated directly and/or indirectly through a connecting molecule.
|
