发明名称 |
PNA probes for detection of Neisseria gonorrhoeae and Chlamydia trachomatis |
摘要 |
Specific peptide nucleic acid (PNA) probes for detecting a sexual transmitted disease caused by Neisseria gonorrhoeae or Chlamydia trachomatis comprising N-(2-aminoethyl)glycine units in amide linkage with the glycine nitrogen connected to naturally occurring nucleobases or non-naturally occurring nucleobases by a methylene carbonyl linker and said probes capable of hybridizing to 16S or 23S rRNA or rDNA of Neisseria gonorrhoeae or Chlamydia trachomatis are described. PNA is a very stable molecule with very high affinity for nucleic acid allowing a PNA probe to be shorter than conventional nucleic acid probes.
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申请公布号 |
US6169169(B1) |
申请公布日期 |
2001.01.02 |
申请号 |
US19950443930 |
申请日期 |
1995.05.18 |
申请人 |
DAKO A/S |
发明人 |
HYLDIG-NIELSEN JENS JOERGEN;GODSKESEN MICHAEL ANDERS |
分类号 |
C12N15/09;C07H19/00;C07H21/02;C07H21/04;C07K14/00;C07K14/22;C07K14/295;C12Q1/68;(IPC1-7):C12Q1/68;A01N43/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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