| 摘要 |
Graft rejection and graft versus host disease after HLA-identical stem cell transplantation is the result of recognition of minor histocompatibility antigens on donor stem cells by immunocompetent T lymphocytes from recipient origin. T lymphocyte clones specifically recognizing H-Y epitopes on male target cells have been generated during graft-rejection after sex-mismatched transplantation. Previously, two human H-Y epitopes derived from the same SMCY gene have been identified that were involved in bone marrow graft rejection. Here, we report the identification of a new male-specific transplantation antigen encoded by the Y-chromosome-specific gene DFFRY. The DFFRY-derived peptide was recognized by a HLA-A1 restricted CTL clone, which was generated during graft rejection from a female patient with acute myeloid leukemia who rejected her HLA-phenotypically identical bone marrow from her father. The identification of this gene demonstrates that at least two genes present on the human Y-chromosome code for male-specific transplantation antigens. |
