Bacteriocin, preparation and use thereof

摘要

High molecular weight bacteriocin (I) contains at least one large subunit in which the N-terminal sequence is homologous with that of the phage 186 tube protein (II) and at least one second large subunit in which the N-terminal sequence is homologous with that of the P2 phage mantle protein (III). The N-terminal sequence for (II) is ALPRKLKYLNMFNDGLSYMGVV and that for (III) is DYHHGVQVL. Independent claims are also included for the following: (a) phytopharmaceutical composition containing at least one (I) and a carrier; Serratia plymuthia LMG P-18951, or its variants or mutants, able to produce (I); (b) DNA fragment encoding (I); and (c) production of (I) by growing the appropriate strains of S. plymuthia.