发明名称 |
Generation of antigen specific T suppressor cells for treatment of rejection |
摘要 |
This invention also provides a method of generating antigen specific human suppressor CD8+CD28- T cells. This invention further provides a method of generating allopeptide antigen specific human suppressor CD8+CD28- T cells. Methods of tent for reduction of risk of rejection of allografts and xenografts and autoimmune diseases using the human suppressor CD8+CD28- T cells so produced are also provided, as are methods of preventing rejection and autoimmune diseases, and vaccines comprising the produced suppressor T cells. Methods of diagnosis to determine whether a level of immuno-suppressant therapy requires a reduction are provided. |
申请公布号 |
AU5875600(A) |
申请公布日期 |
2001.01.02 |
申请号 |
AU20000058756 |
申请日期 |
2000.06.15 |
申请人 |
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE |
发明人 |
NICOLE SUCIU-FOCA;RAFFAELLO CORTENSINI;ZHUORU LIU;CHIH-CHAO CHANG |
分类号 |
A61K35/12;A61K39/00;C12N5/02;C12N5/08;C12Q1/68;G01N33/53;G01N33/567;G01N33/569 |
主分类号 |
A61K35/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|