发明名称 |
Processes for the synthesis of oligomeric compounds |
摘要 |
The present invention provides synthetic processes by which oligomeric compounds, having at least one phosphodiester or phosphorothioate linkage, are prepared. The synthetic processes use a novel mixture of concentrated ammonium hydroxide and a thiol compound during the deblocking step of all or selected internucleoside linkages. Alternatively, the deblocking is carried out in two steps using a mercapto compound in an aqueous amine followed by concentrated ammonium hydroxide. Also provided are synthetic intermediates useful in such processes. Novel oxidation procedures to give phosphodiester oligomers are also included.
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申请公布号 |
US6169177(B1) |
申请公布日期 |
2001.01.02 |
申请号 |
US19980187995 |
申请日期 |
1998.11.06 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
MANOHARAN MUTHIAH |
分类号 |
C07H21/00;(IPC1-7):C07H21/00;C07H21/02;C07H21/04 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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