发明名称 |
PHARMACEUTICALLY ACTIVE COMPOUNDS AND LIPOSOMES, AND METHODS OF USE THEROF |
摘要 |
<p>This invention provides a compound having the formula R<1>-Y<1>-CHZ<1>-CH(NY<2>Y<3>)-CH2-Z<2>, wherein: R<1> is a straight-chained alkyl, alkenyl or alkynyl group having from 8 to 19 carbon atoms in the aliphatic chain; Y<1> is -CH=CH-, -C PARALLEL C- or -CH(OH)CH(OH)-; Z<1> is OH or a conversion-inhibiting group; Z<2> is a conversion-inhibiting group; Y<2> is H, phenyl group, an alkylsubstituted phenyl group having from 1 to about 6 carbons in the alkyl chain, or an alkyl chain having from 1 to 6 carbons; Y<3> is H or a group having the formula -C(O)R<2> or -S(O)2R<2>; R<2> is a straight-chained alkyl, alkenyl, alkynyl group having from 1 to 23 carbon atoms in the chain; and when Z<2> is an amino, R<2> is an aliphatic chain having from 1 to 9 or from 19 to 23 carbon atoms in the aliphatic chain.</p> |
申请公布号 |
GR3034521(T3) |
申请公布日期 |
2000.12.29 |
申请号 |
GR20000402211T |
申请日期 |
2000.09.29 |
申请人 |
THE LIPOSOME COMPANY, INC. |
发明人 |
PEI, YONG-WEI;MAYHEW, ERIC;AHMAD, IMRAN;JANOFF, ANDREW, S. |
分类号 |
A61K9/127;A61K31/13;A61K31/135;A61K31/16;A61K31/164;A61K31/165;A61K31/18;A61K31/695;A61K38/00;A61P35/00;B01J13/02;C07C211/21;C07C211/22;C07C211/45;C07C211/49;C07C215/02;C07C219/02;C07C229/02;C07C233/18;C07C233/31;C07C311/03;C07C311/11;C07C317/28;C07F7/18;C07F9/06;(IPC1-7):C07F7/18 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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