PROCESS FOR THE PREPARATION OF AMIDINO PHENYL PYRROLIDINE -g(b)-ALANINE UREA ANALOGS

摘要

The invention herein is directed to a process for producing a lactam of the formula from a methionine analog of the formula by treating the methionine analog with trimethylsulfonium halide or trimethylsulfoxonium halide in the presence of a base in a suitable aprotic solvent. The invention herein is further directed to the preparation of amidinophenyl pyrrolidinyl beta -alanine urea analogs using such methionine and lactam compounds as intermediates, which beta -alanine urea analogs are useful as antithrombotics.