发明名称 |
METHOD FOR INCREASING BLOOD-BRAIN BARRIER PERMEABILITY. |
摘要 |
<p>The permeability of the blood-brain barrier to endogenous or exogenous neuropharmaceutical or diagnostic agents in an individual's blood stream is increased by administering a bradykinin agonist of blood-brain barrier permeability, such as N-acetyl [Phe8(CH2-NH)Arg9 ] bradykinin, to the individual. The bradykinin agonist of blood-brain barrier permeability is co-administered with the agent of interest into a blood vessel such as a vein. This co-administration allows the agent of interest to pass the blood-brain barrier into the brain compartment.</p> |
申请公布号 |
GR3034351(T3) |
申请公布日期 |
2000.12.29 |
申请号 |
GR20000402039T |
申请日期 |
2000.09.06 |
申请人 |
ALKERMES, INC. |
发明人 |
MALFROY-CAMINE, BERNARD;SMART, JANET, L. |
分类号 |
A61K31/70;A61K33/24;A61K38/00;A61K38/04;A61K47/42;A61K49/00;A61K51/00;A61P25/00;A61P43/00;C07K7/18;(IPC1-7):A61K31/70;A61K37/02;A61K31/71;C07K99/18 |
主分类号 |
A61K31/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|