发明名称 |
NOVEL PYRRHOCORICIN-DERIVED PEPTIDES, AND METHODS OF USE THEREOF |
摘要 |
Modifications of the peptide pyrrhocoricin permit the production of a variet y of anti-bacterial or anti-fungal peptides having general formula R1-Asp-Lys- Gly-X-Y-Leu-Pro-Arg-Pro-Thr-Pro-Pro-Arg-Pro-Ile-Tyr-X'-Y'-R2[SEQ ID NO:1] or multimeric compositions containing more than a single peptide of that formul a. These peptides may be straight chain or cyclic peptides, and may contain one or more non-cleavable bonds. These peptides are characterized by anti- bacterial or anti-fungal activity and metabolic stability in mammalian serum . These peptides are useful in anti-bacterial or anti-fungal pharmaceutical compositions and for further drug development or identification of other antibiotic or anti-fungal compounds.
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申请公布号 |
CA2375502(A1) |
申请公布日期 |
2000.12.28 |
申请号 |
CA20002375502 |
申请日期 |
2000.06.21 |
申请人 |
THE WISTAR INSTITUTE OF ANATOMY & BIOLOGY |
发明人 |
OTVOS, LASZLO JR. |
分类号 |
A61K38/00;C07K7/08;C07K9/00;C07K14/435;C12N15/12;(IPC1-7):C12N15/12;C07K7/00;C12N15/63;C12N15/82 |
主分类号 |
A61K38/00 |
代理机构 |
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