发明名称 |
Methods and compositions for modulating drug activity through telomere damage |
摘要 |
The invention provides methods and compositions for modulating the activity of therapeutic agents for the treatment of a cancer by administering one or more agents that (either alone or in combination) induces telomere damage and inhibits telomerase activity in the cancer cell. The method initially uses, e.g., a telomere damage-inducing agent such as paclitaxel, and a telomerase inhibitory agent such as AZT. The invention also provides methods for identifying other agents with telomere damage-inducing activity and/or telomerase inhibitory activity (as well as and compositions having such activity), for use in the treatment of cancer. |
申请公布号 |
AU5466500(A) |
申请公布日期 |
2000.12.28 |
申请号 |
AU20000054665 |
申请日期 |
2000.06.05 |
申请人 |
JESSIE L.-S. AU;GUILLAUME WIENTJES |
发明人 |
JESSIE L.-S. AU;GUILLAUME WIENTJES |
分类号 |
A61K31/337;A61K45/06;A61P35/00;C12Q1/68;G01N33/50 |
主分类号 |
A61K31/337 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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