发明名称 |
POLYMORPHS OF CRYSTALLINE AZO-BICYCLO 2,2,2,OCT-3-YL AMINE DIHYDROCHLORIDE AND THEIR PHARMACEUTICAL COMPOSITIONS |
摘要 |
Two crystalline polymorphic forms of (2-Benzhydryl-1-azo-bicyclo[2,2,2]Octyl -3- yl)-(5-iso-propyl-2-methoxybenzyl)amine dihydrochloride dihydrate are Form I and Form II. The pharmaceutical composition containing at least one of these polymorphs has advantageous stability for formulation to treat emesis in patients receiving chemotherapy. The administration of this pharmaceutical composition is conventional oral by preferably tablet or capsule or intravenous. A method of making Forms I and II is also disclosed.
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申请公布号 |
CA2375265(A1) |
申请公布日期 |
2000.12.28 |
申请号 |
CA20002375265 |
申请日期 |
2000.06.06 |
申请人 |
PFIZER PRODUCTS INC., |
发明人 |
ALLEN, DOUGLAS JOHN MELDRUM;APPLETON, TROY ANTHONY;MUEHLBAUER, DAVID JOSEPH;GUMKOWSKI, MICHAEL JON;NORRIS, TIMOTHY |
分类号 |
A61K;A61K31/13;A61K31/435;A61K31/439;A61P;A61P1/08;A61P25/28;A61P43/00;C07C9/00;C07C11/00;C07D;C07D453/02;(IPC1-7):C07D453/02 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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地址 |
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