BIOLOGIC REPLACEMENT FOR FIBRIN CLOT FOR INTRA-ARTICULAR USE

摘要

This invention provides a 3-D scaffold composition for repairing a ruptured anterior cruciate ligament and a method for attaching the composition to the ruptured anterior cruciate ligament. The scaffold has an inductive core and an adhesive zone. After the scaffold composition is inserted into the region between the torn ends of the anterior cruciate ligament and adhesively attached to the ends of the ligament, the adhesive zone provides a microenvironment for inducing fibroblast cells from the anterior cruciate ligament to migrate into the inductive core. After migrating into the inductive core, the fibroblast cells conform to the collagen structure betwe en the ligament and heal the gap between the ruptured ends. The invention also includes the use of a collagen-based glue as an adhesive to maintain contact between the torn edges of the meniscus and the use of a collagen-based scaffold as an adhesive (as well as a cell migration inducer) to maintain an d restore contact between the torn cartilage and the surrounding cartilage and bone.