New gene encoding the G-protein coupled receptor hLPACR1, useful for diagnosis and gene therapy treatment of associated diseases

摘要

A gene (I) encoding the human receptor (II) designated hLPACR1 (human lysophosphatidic acid (LPA)-like receptor-1), is new. Independent claims are also included for the following: (1) transcription factors, RNA polymerases, pharmaceuticals and chemicals that modulate expression of (I); (2) mRNA, including splice variants and isoforms, transcribed from (I); (3) cDNA derived from the mRNA of (2) or from intron-less genes; (4) a protein (IIa) derived/produced from (I), the cDNA of (3) or mRNA of (2); (5) antibodies and antisera raised against epitopes of (IIa), or against the whole protein; (6) expression systems that produce native or recombinant (IIa); (7) ligand-binding studies and screening assays using native or recombinant (II), or cells or cell membranes that contain (II); (8) transgenic or knockout animals that express (II) at altered levels or not at all; and (9) sense and antisense oligonucleotides derived from (I).