PROCESS FOR PRODUCING 3-FLUORO OXINDOLE DERIVATIVES AND INTERMEDIATES OF THE PREPARATION

摘要

Preparation of oxindole compounds of formula (I) comprises: (a) reducing the nitro compound of formula (II) or its salt with a reducing agent to produce an intermediate amino compound of formula (III); and (b) cyclising (III). R = H, a carboxy protecting group of a cation of an addition salt. Also claimed is a process for preparing racemic (II) or its salt comprising: (a) fluorinating the compound of formula (IV); and optionally (b) hydrolysing the carboxy protecting group to give (II; R = H or cation). R1 = carboxy protecting group. (III) are new.