| 摘要 |
Rapidly disintegrating tablet for oral administration which comprises a compacted mixture of methylcellulose having a viscosity greater than 1000 centipoise; and an edible calcium salt. - Independent claims are also included for: (1) a tablet comprising: methylcellulose with a viscosity greater than 3000 centipoise; dibasic calcium phosphate; sodium starch glycolate; magnesium stearate; sodium lauryl sulphate; povidone. (2) a process for preparing a tablet which comprises: (a) compacting and blending together an intragranular mixture high viscosity methylcellulose of greater than 3000 centipoises, a wetting agent, povidone or sodium starch glycolate, and an edible calcium salt; (b) adding to the mixture from step (a) a PVP aqueous solution, or alternatively spraying the mixture of step (a) with a PVP aqueous solution, and preparing granulates; (c) blending together an edible calcium salt, povidone or sodium starch glycolate, a wetting agent, a lubricating agent or mixtures thereof; (d) compacting the granulates of step (b) with the extragranular mixture of step (c). |
