发明名称 4-ARYLOXY- AND 4-ARYLTHIOPIPERIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION
摘要 Novel 4-aryloxy- or 4-arylthiopiperidine derivatives of the formula I <IMAGE> in which R<1> and R<2> in each case independently of one another are phenyl radicals which are unsubstituted or substituted one or two times by A, OH, OA, aryloxy having 6-10 C atoms, aralkyloxy having 7-11 C atoms, -O-(CH2)n-O-, Hal, CF3, NO2, NH2, NHA, NA2, NHAc, NAAc, NHSO2A and/or NASO2A, X is O, S, SO or SO2, m is 1, 2 or 3, n is 1 or 2, A is an alkyl radical having 1-6 C atoms, Hal is F, Cl, Br or I and Ac is alkanoyl having 1-8 C atoms, aralkanoyl having 1-10 C atoms or aroyl having 7-11 C atoms, and their physiologically acceptable salts, have an action affecting the central nervous system, in particular neuroleptic action, without a noticeable cataleptic action occurring.
申请公布号 HU218912(B) 申请公布日期 2000.12.28
申请号 HU19940002154 申请日期 1994.07.21
申请人 MERCK Patent GmbH 发明人 BARTOSZYK, GERD;DR.GOTTSCHLICH, RUDOLF;PRUECHER, HELMUT;DR.SEYFRIED, CHRISTOPH
分类号 A61K31/445;A61K31/42;A61K31/4465;A61K31/4523;A61P9/12;A61P25/04;A61P25/18;A61P25/22;A61P25/24;A61P25/26;C07D211/54;C07D263/20;C07D413/06;C07D413/14 主分类号 A61K31/445
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