| 摘要 |
Human antithrombin variants showing a high protease inhibitory activity even in the absence of heparin wherein at least one of the amino acids at the 78-, 278-, 378- and 380-positions in the amino acid sequence of natural human antithrombin is substituted by another amino acid. Preferable examples thereof are human antithrombin variants wherein the amino acid at the 78-position is substituted by Phe; the amino acid at the 278-position is substituted by Ala, Arg, Asn, Gly, His, Tyr or Val; the amino acid at the 378-position is substituted by Lys, Asn or Val; and/or the amino acid at the 380-position is substituted by Ala, Asp, Gly, His, Ile, Leu, Asn, Pro, Arg, Thr, Tyr or Val.
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