.ALPHA.1B-ADRENERGIC RECEPTOR ANTAGONISTS

摘要

Compounds of the general formula (I) or pharmacologically acceptable acid addition salts thereof; and .alpha.1B-adrenergic receptor antagonists comprising the compounds or the salts: [wherein Ar is indole or the like; R1 is hydrogen or the like; B is a bond or B-N-R1 may form a ring structure suc h as piperidine; n is 0, 1 or the like; A is trimethylene, butylene, or the like; and Q is piperidine, isoindoline, or the like]. The compounds and the salts serve as antagonists having a high affinity for .alpha.1B-adrenergic receptor and are useful as drugs to be used in the prevention and/or treatme nt of .alpha.1B-adrenergic receptor-related diseases (such as hypertension) or as pharmacological tools for the elucidation of physiologic actions occurring through .alpha.1B-adrenergic receptor.