| 摘要 |
This invention encompasses various methods of modulating protein levels using the SKP1, CDC53/Cullin, F-box(SCF) protein complex. More specifically, the present invention provides various methods of target protein degradation using targeted ubiquitination techniques. The present invention also provides various compositions and assays associated with the disclosed modulation of protein levels using the SCF complex as well as various methods of detecting, monitoring and treating cancerous cells. |
