发明名称 |
Siv-based packaging-defficient vectors |
摘要 |
A simian Immunodeficiency Virus (SIV) genome having a mutation within the packaging signal such that viral RNA is not packaged within an SIV capsid is described. A viral vector comprises an SIV packaging signal and a heterologous gene capable of being expressed in the vector. The packaging defective SIV genome and viral vector may be co-transfected into a host cell to produce SIV virus particles capable of expressing a heterologous gene. |
申请公布号 |
AU5543700(A) |
申请公布日期 |
2000.12.28 |
申请号 |
AU20000055437 |
申请日期 |
2000.06.09 |
申请人 |
SYNGENIX LIMITED |
发明人 |
ANDREW LEVER;JANE GREATOREX;EAMON MCCANN;PREETHA BALAN;JOAN THOMAS |
分类号 |
C12N15/09;A61K31/7088;A61K35/76;A61K48/00;A61P31/14;A61P31/18;C12N7/00;C12N15/867;C12R1/93 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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