| 摘要 |
<p>Antimicrobial compounds of formula (I) are disclosed: R1-X-R2 wherein X is a group comprising of from about 4 to about 10 amino acids, wherein at least one of the amide (--CONH--) linkages is replaced by --NRcCRaRb--; Ra, Rb, and Rc are each independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C8)cycloalkyl, (C1-C6)alkoxycarbonyl, aryl, or heterocycle; and R1 and R2 are each independently hydrogen, a saccharide, a lipid, a solubilizing agents, or a suitable protecting group; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising such compounds or salts, and methods of using such compounds or salts to treat a bacterial infection.</p> |
