POLYMORPHS OF CRYSTALLINE (2-BENZHYDRYL-1-AZABICYCLO[2,2,2]OCT-3-YL)-(5-ISOPROPYL-2-METHOXYBENZYL)-AMMONIUMCHLORIDE AS NK-1 RECEPTOR ANTAGONISTS

摘要

Two crystalline polymorphic forms of (2-Benzhydryl-1-azo-bicyclo[2,2,2]Octyl-3-yl)-(5-iso-propyl-2-methoxybenzyl)amine dihydrochloride dihydrate are Form I and Form II. The pharmaceutical composition containing at least one of these polymorphs has advantageous stability for formulation to treat emesis in patients receiving chemotherapy. The administration of this pharmaceutical composition is conventional oral by preferably tablet or capsule or intravenous. A method of making Forms I and II is also disclosed.