发明名称 NON-MALIGNANT DISEASE TREATMENT WITH RAS ANTAGONISTS
摘要 Disclosed is a method for inhibiting Ras-induced or mediated proliferation o f cells associated with a non-malignant disease, disorder or pathological condition. The method entails administering to a patient a Ras antagonist in an amount effective to inhibit the proliferation. The invention is particularly applicable to diseases characterized by a proliferation of T- cells such as autoimmune disease, e.g., type 1 diabetes, lupus and multiple sclerosis, and pathological states such as graft rejection induced by the presentation of a foreign antigen such as a graft in response to a disease condition (e.g., kidney failure). Other non-malignant diseases characterized by proliferations of cells include cirrhosis of the liver and restenosis. Preferred Ras antagonists are S-trans-trans farnesylthiosalicylic acid (FTS) and structurally related compounds (or analogs) thereof.
申请公布号 CA2377254(A1) 申请公布日期 2000.12.28
申请号 CA20002377254 申请日期 2000.06.19
申请人 THYREOS CORPORATION;RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT 发明人 REIF, SHIMON;CHAPMAN, JOAB;BROWNSTEIN, MICHAEL;BRUCK, RAFAEL;KLOOG, YOEL
分类号 C07D213/70;A61K31/00;A61K31/18;A61K31/185;A61K31/192;A61K31/196;A61K31/21;A61K31/235;A61K31/44;A61K31/455;A61K31/465;A61K31/60;A61K31/606;A61K45/00;A61P1/16;A61P25/00;A61P37/00;(IPC1-7):A61K31/60 主分类号 C07D213/70
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