| 摘要 |
Target cells (A) are inactivated in presence of T cells by contacting both cell types with a superantigen (Sag) in presence of an immune modulator (IM). The new feature is that at least one of SAg and IM is present as a conjugate between a 'free' superantigen and a component (T) that targets the conjugate to (A). Also new are: (1) Sag conjugates of formula (T)x(Sag)y(IM)z (I), Sag, IM (not a superantigen) and T are linked via organic linkers, same or different, x, y and z are integers typically 0-10, provided that y and at least one of x and z must be greater than zero; (2) targeted IM conjugates of formula (T)x(Sag)y(IM')z (V), IM' = IM in which affinity for lymphocyte receptors or rate of internalisation when bound to this receptor has been reduced, e.g. by mutation; here z and at least one of x and y must be greater than zero; (3) DNA (II) encoding an Sag and an IM, especially interleukin-2 (IL-2), that is not an Sag. |
