发明名称 |
Alpha or beta emitters attached to fragments in radioimmunotherapy |
摘要 |
The present invention relates to radioimmunoconjugates useful in targeted radioimmunotherapy and methods of treating a patient using radioimmunoconjugates. The radioimmunoconjugates of the present invention comprise an alpha- or beta-emitting radioisotope and a binding site linked to or on an antigen-binding fragment of an antibody which specifically binds to a tumor-associated antigen. The methods of treating a patient can include administering one or more clearing agents to the patient in conjunction with the radioimmunoconjugate of the present invention, as well as subsequently grafting bone-marrow or autologous stem-cells to the patient. |
申请公布号 |
AU5727000(A) |
申请公布日期 |
2000.12.28 |
申请号 |
AU20000057270 |
申请日期 |
2000.06.07 |
申请人 |
CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY |
发明人 |
DAVID M GOLDENBERG;THOMAS M BEHR |
分类号 |
A61K45/00;A61K31/198;A61K35/28;A61K39/395;A61K47/48;A61K51/00;A61K51/10;A61P35/00;A61P39/02;C07K16/00 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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